| Mon, Mar 24 | Girls Varsity Softball (A) vs South Dearborn | W 20-1 | 1-1 |
| Tue, Mar 25 | Girls Junior Varsity Softball (H) vs Mercy McAuley | 5:00 PM | William Henry Harrison High School |
| Thu, Mar 27 | Girls Varsity Softball (H) vs Ross | 5:00 PM | William Henry Harrison High School |
| | Girls Junior Varsity Softball (A) vs Ross | 5:00 PM | Ross High School |
| Fri, Mar 28 | Girls Varsity Softball (A) vs Oak Hills | 5:00 PM | Rapid Run Middle School |
| | Girls Junior Varsity Softball (A) vs Oak Hills | 5:00 PM | Rapid Run Middle School |
| Mon, Mar 31 | Girls Varsity Softball (H) vs Mt. Healthy | 5:00 PM | William Henry Harrison High School |
| Tue, Apr 01 | Girls Varsity Softball (H) vs Mt. Notre Dame | 5:00 PM | William Henry Harrison High School |
| Wed, Apr 02 | Girls Varsity Softball (H) vs Northwest | 5:00 PM | William Henry Harrison High School |
| Fri, Apr 04 | Girls Varsity Softball (H) vs Fairmont | 5:00 PM | William Henry Harrison High School |
| | Girls Junior Varsity Softball (A) vs Fairmont | 5:00 PM | Fairmont High School |
| Mon, Apr 07 | Girls Varsity Softball (H) vs Talawanda | 5:00 PM | William Henry Harrison High School |
| Wed, Apr 09 | Girls Varsity Softball (A) vs Mt. Healthy | 5:00 PM | Mt. Healthy High School |
| Thu, Apr 10 | Girls Varsity Softball (H) vs Lawrenceburg | 5:30 PM | William Henry Harrison High School |
| Mon, Apr 14 | Girls Varsity Softball (A) vs Northwest | TBA | Northwest High School |
| Tue, Apr 15 | Girls Varsity Softball (A) vs Loveland | TBA | Loveland High School |
| Wed, Apr 16 | Girls Varsity Softball (A) vs Talawanda | 5:00 PM | Talawanda High School |
| | Girls Junior Varsity Softball (A) vs Little Miami | 5:00 PM | Little Miami High School |
| Sat, Apr 19 | Girls Varsity Softball (A) vs Troy | 11:00 AM | Troy High School |
| | Girls Junior Varsity Softball (A) vs Lebanon | 11:00 AM | Lebanon High School |
| | Girls Varsity Softball (A) vs TBD | 1:00 PM | Troy High School |
| Mon, Apr 21 | Girls Varsity Softball (H) vs Mt. Healthy | TBA | William Henry Harrison High School |
| Wed, Apr 23 | Girls Varsity Softball (H) vs Northwest | TBA | William Henry Harrison High School |
| Thu, Apr 24 | Girls Varsity Softball (H) vs Lakota East | 5:00 PM | William Henry Harrison High School |
| | Girls Junior Varsity Softball (A) vs Lakota East | 5:00 PM | Lakota East High School |
| Fri, Apr 25 | Girls Junior Varsity Softball (H) vs Little Miami | 5:00 PM | William Henry Harrison High School |
| Mon, Apr 28 | Girls Varsity Softball (H) vs Talawanda | TBA | William Henry Harrison High School |
| Tue, Apr 29 | Girls Varsity Softball (H) vs Fairfield | 5:00 PM | William Henry Harrison High School |
| | Girls Junior Varsity Softball (A) vs Fairfield | 5:00 PM | Fairfield Middle School |
| Fri, May 02 | Girls Varsity Softball (A) vs East Central | TBA | East Central High School |
| Tue, May 06 | Girls Junior Varsity Softball (H) vs Milford | 5:00 PM | William Henry Harrison High School |
| | Girls Varsity Softball (A) vs Milford | 5:00 PM | Milford High School |
| Wed, May 07 | Girls Junior Varsity Softball (H) vs East Central | 5:00 PM | William Henry Harrison High School |
| | Girls Varsity Softball (A) vs Highlands | 5:00 PM | Highlands High School |
| Thu, May 08 | Girls Varsity Softball (A) vs Seton | 5:00 PM | Delhi Park |
| | Girls Junior Varsity Softball (H) vs Seton | 5:00 PM | William Henry Harrison High School |
| Fri, May 09 | Girls Junior Varsity Softball (A) vs Western Brown | 5:00 PM | Western Brown High School |
| | Girls Varsity Softball (A) vs Western Brown | 7:00 PM | Western Brown High School |
| Sat, May 10 | Girls Varsity Softball (A) vs TBD | TBA | Dixie Heights High School |
| | Girls Varsity Softball (A) vs Dixie Heights | TBA | Dixie Heights High School |